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T3359 |
Aprotinin
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Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin |
Others
,
Serine Protease
,
Influenza Virus
,
Proteasome
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Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat... |
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T76240 |
Urinary Trypsin Inhibitor Fragment
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Urinary Trypsin Inhibitor Fragment, a proteolytically derived segment of urinary trypsin inhibitor, demonstrates the capability to inhibit tumor cell invasion through limited proteolysis [1]. |
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T8362 |
Benzamidine hydrochloride
|
Benzamidine HCl |
Serine/threonin kinase
,
Serine Protease
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Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively). |
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T17011 |
TCH-165
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Proteasome
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TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs. |
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T8802 |
2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
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2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-fur |
Serine Protease
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2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or synthetically produced. |
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T30519 |
BMS-363131
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BMS363131,BMS 363131 |
Serine Protease
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BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM. |
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T6370 |
AEBSF hydrochloride
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AEBSF HCl,Pefabloc SC |
Thrombin
,
Serine Protease
,
Influenza Virus
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AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin. |
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T6941 |
PI-1840
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PI 1840 |
PARP
,
Proteasome
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PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). |
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T16169 |
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
|
N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride |
Others
,
Proteasome
,
COX
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N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride exhib... |
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T2391 |
Camostat mesylate
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FOY-S980,FOY305,Camostat mesilate |
Serine/threonin kinase
,
SARS-CoV
,
Sodium Channel
|
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Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function. |
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T60248 |
4-Aminobenzamidine dihydrochloride
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p-Aminobenzamidine dihydrochloride |
Serine Protease
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4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inh... |
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T9670L |
Patamostat HCl
|
Patamostat HCl（114568-26-2 Free base） |
Serine Protease
,
Protease
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Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamosta... |
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T7016 |
VR23
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Apoptosis
,
Proteasome
,
Caspase
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VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes. |
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T2122 |
Ixazomib
|
MLN2238 |
Proteasome
,
Caspase
,
Autophagy
|
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Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i... |
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T67959 |
Pirodomast
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Thrombin
,
Serine Protease
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Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospas... |
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T9351 |
Nirmatrelvir
|
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SARS-CoV
|
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PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) . |
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T29969 |
AMG-126737
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105RSZ5CNS,AMG 126737,SCHEMBL7986111 |
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AMG-126737 is an effective human lung mast cell trypsin inhibitor with potential therapeutic effect in lung diseases. |
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T30510 |
BMS-262084
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BMS 262084,I0IR71971G,UNII-I0IR71971G,CHEMBL71037 |
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BMS-262084 is a potent selective β-lactam trypsin inhibitor with therapeutic potential in the treatment of asthma. |
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T62464 |
Bz-D-Arg-pNA hydrochloride
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Bz-D-Arg-pNA hydrochloride is a competitive trypsin inhibitor. |
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T77221 |
Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)
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Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptas... |
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T39029 |
APC-6860
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|
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APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA ve... |
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T37019 |
P-APMSF (hydrochloride)
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p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these pr... |
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T6564L |
Leupeptin
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Leupeptin Ac-LL,NK-381 |
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Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), ... |
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TP2056 |
Acetyl-Calpastatin(184-210)(human)
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Acetyl-Calpastatin (184-210) (human) |
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Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. |
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T36962 |
MMP Inhibitor I (trifluoroacetate salt)
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MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urea... |
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T38521 |
Patamostat mesylate
|
E-3123 mesylate |
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Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compoun... |
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TP2217 |
Alpha-1 antitrypsin fragment
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Others
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Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the ma... |
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T72736 |
Aeruginosin 98-B
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Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively. |
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T68474 |
RWJ-58643 HCl
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RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher dos... |
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T69297 |
Leupeptin HCl
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Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin... |
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T41085 |
UK122
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UK122 |
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UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA),... |
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T70834 |
BE-16627B
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BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 da... |
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T9670 |
Patamostat
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|
|
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Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin, exhibiting IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests that Patamostat might supp... |
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T27698 |
JTV-803 mesylate
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JTV803,JTV 803,JTV-803 |
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JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting ... |
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T79444 |
HA-IN-1
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Influenza Virus
|
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HA-IN-1 (compound 5g), a high-affinity Hemagglutinin (HA) ligand, targets the trypsin cleavage site of HA to inhibit HA-mediated membrane fusion and decrease pulmonary virus titer in vivo. This compound emerges as a prom... |
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T62846 |
Freselestat quarterhydrate
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Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent, orally active inhibitor of neutrophil elastase (Ki: 12.2 nM). quarterhydrate is more than 100-fold less active than other proteases such as trypsin, prote... |
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T38052 |
CRA-2059 TFA
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|
|
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CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Tryptase is a trypsin-like serine protease found as a major protein component in human ma... |
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T38051 |
CRA-2059 hydrochloride
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|
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CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Tryptase is a trypsin-like serine protease found as a major protein compone... |
